Products By Therapeutical Index
Infections
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Antibiotics
Indications
Zinex is indicated for the treatment of infections caused by susceptible strains of the following organisms in the following infections:
· Pharyngitis and tonsillitis caused by Streptococcus pyogenes.
· Otitis media caused by Streptococcus pneumoniae, Haemophilus influenza (ampicillin- sensitive and resistant strains), Moraxella (Branhamella) catarrhalis and Streptococcus pyogenes.
· Sinusitis caused by Streptococcus pneumoniae and Haemophilus influenza.
· Acute and chronic bronchitis caused by Streptococcus pneumoniae, Haemophilus influenza (ampicillin-sensitive strains) and Haemophilus parainfluenzae (ampicillin-sensitive strains).
· Acute uncomplicated cystitis caused by Escherichia coli and Klebsiella pneumoniae.
· Lyme disease caused by Borrelia burgdorferi.
Composition
Each tablet contains Cefuroxime (as axetil) 250 or 500 mg
Action
Cefuroxime axetil owes its bactericidal activity to the parent compound cefuroxime. Cefuroxime is a well-characterized and effective antibacterial agent that has bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains.
Cefuroxime has good stability to bacterial β-lactamase, and consequently is active against many ampicillin-resistant or amoxycillin-resistant strains. The bactericidal action of cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins.
